Papers

Basic information

Name OZAWA Hitoshi

Title

Changes in the expression of corticotrophin-releasing hormone, mineralocorticoid receptor and glucocorticoid receptor mRNAs in the hypothalamic paraventricular nucleus induced by fornix transection and adrenalectomy

Author

F. Han,H. Ozawa,K. I. Matsuda,H. Lu,E. R. De Kloet,M. Kawata

Sole or Joint Author

 

Journal

Journal of Neuroendocrinology

Publisher

 

All Volumes

 

All Pages

 

Volume

19

Number

4

Starting Page

229

Ending Page

238

Publication Date

2007-04

Referee Paper

Refereed

Invited Paper

Not invited

Language

English

MISC Class

 

Publishing Type

Research paper (scientific journal)

ISSN

 

ID:DOI

10.1111/j.1365-2826.2006.01519.x

ID:NAID

 

ID:PMID

 

URL

Description

The paraventricular nucleus (PVN) in the hypothalamus receives inputs from the hippocampus. The present study explored the influence of the hippocampus on genes mediating glucocorticoid feedback in the PVN. Accordingly, the expression of mRNAs for corticotrophin-releasing hormone (CRH), the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR) in the PVN was examined by in situ hybridisation in rats subjected to transection of the fornix. Significant increases in CRH, MR and GR mRNAs were observed in the parvocellular PVN after fornix transection (FT). FT-animals subjected to adrenalectomy also showed an increase in the number of cells positive for CRH and GR mRNAs. CRH, MR and GR mRNA expression was also increased by bilateral adrenalectomy, and GR mRNA expression was further enhanced in the parvocellular PVN of the FT transected animals. However, no such changes were evident in the magnocellular PVN. These results suggest that the input from the hippocampus to the PVN, particularly to its parvocellular region, has distinct and differential inhibitory effects on the expression of MR, GR and CRH mRNAs that may operate independently from the feedback actions of corticosterone. © 2007 The Authors. Journal Compilation © 2007 Blackwell Publishing Ltd.

ID:JGlobalID

 

arXiv ID

 

Put Code of ORCID

 

DBLP ID

 

WekoID of OpenDepo